Volume 4, Issue 4, December 2018, Page: 26-32
Prevalence of Depression and Associated Factors in HIV-Positive Adults Attending an Antiretroviral Clinic in Jos, Nigeria
Halima Mwuese Sule, Department of Family Medicine, University of Jos/Jos University Teaching Hospital, Jos, Nigeria
Patricia Aladi Agaba, Department of Family Medicine, University of Jos/Jos University Teaching Hospital, Jos, Nigeria
Raphael Onu Ojoh, Department of Family Medicine, Jos University Teaching Hospital, Jos, Nigeria
Michael Terkura Agbir, Department of Psychiatry, Benue State University, Makurdi, Nigeria
Kingsley Mayowa Okonoda, Department of Psychiatry, University of Jos/Jos University Teaching Hospital, Jos, Nigeria
Received: Nov. 19, 2018;       Accepted: Dec. 5, 2018;       Published: Jan. 14, 2019
DOI: 10.11648/j.jfmhc.20180404.12      View  43      Downloads  12
Clinical depression has been associated with various chronic disease conditions. The chronic course of HIV, fostered by the use of antiretroviral therapy in infected patients, puts them at risk of developing clinical depression which unfortunately, is often underdiagnosed and therefore undertreated. The study estimated the prevalence of depression and associated factors amongst adult patients receiving antiretroviral therapy in a clinic in Jos, using the PHQ-9 questionnaire. Three hundred and fourteen patients with a mean age of 45 ± 10 years were enrolled in a descriptive cross-sectional study. There were 63 males and 251 females, with mean known duration of HIV infection of 11 ± 4 years. Depression was found to be common in the group. Thirty one percent of the patients had depression, and of these, 83 (85%) had mild depression while 12 (12%) had moderate depression and 3 (3%) had moderately severe depression. The factors associated with depression in these patients were analysed using logistic regression. Female gender (P=0.02) as well as age equal to or greater than 45 years (P= 0.03) were shown to be significantly associated with depression. When encountered in such patients, the factors identified to be associated with depression, should serve not only to raise the index of suspicion towards this diagnosis but should also prompt the need to screen for depression. This will contribute to enhancing the chances of diagnosing and treating depression in HIV.
Prevalence, HIV, Depression, Adult, Nigeria
To cite this article
Halima Mwuese Sule, Patricia Aladi Agaba, Raphael Onu Ojoh, Michael Terkura Agbir, Kingsley Mayowa Okonoda, Prevalence of Depression and Associated Factors in HIV-Positive Adults Attending an Antiretroviral Clinic in Jos, Nigeria, Journal of Family Medicine and Health Care. Vol. 4, No. 4, 2018, pp. 26-32. doi: 10.11648/j.jfmhc.20180404.12
Copyright © 2018 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
WHO 2017. Depression. Available from: http://www.who.int/mental_health/management/depression/en/ Accessed on May 18, 2018.
Ferrari AJ, Charlson FJ, Norman RE, Patten SB, Freedman G, Murray CJ et al. Burden of depressive disorders by country, sex, age and year: findings from the Global Burden of Disease Study 2010. PLoS Med. 2013; 10(11): e1001547.
WHO 2017. Global Health Observatory data. Available from: http://www.who.int/gho/hiv/en/ . Accessed on May 18, 2018.
Calvin J. HIV/AIDS, chronic diseases and globalisation. Global Health. 2011; 7:31
Benton T. Depression and HIV/AIDS. Curr Psych Rep.2008; 10(3): 280-5.
WHO 2018. Depression. Available from: http://www.who.int/news-room/fact-sheets/detail/depression . Accessed November 17, 2018
Rabkin JG. HIV and Depression: 2008 review and update. Curr HIV/AIDS Rep. 2008; 5(4):163-71.
Brandt R. The mental health of people living with HIV/AIDS in Africa: a systematic review. Afr J AIDS Res. 2009; 8(2):123-33.
Valente SM. Depression and HIV disease. J Assoc Nurses AIDS Care. 2003; 14(2): 41-51.
Do AN, Rosenberg ES, Sullivan PS, Beer L, Strine TW, Schulden JD, Fagan JL et al. Excess burden of depression among HIV-infected persons receiving medical care in the United States: Data from the medical monitoring project and the behavioral risk factor surveillance system. PLoS ONE. 2014; 9(3): e92842.
Chikezie UE, Otakpor AN, Kuteyi OB, James BO. Depression among people living with human immunodeficiency virus infection/acquired immunodeficiency syndrome in Benin City, Nigeria: A comparative study. Niger J Clin Pract. 2013; 16(2):238-42.
Ciesla J. A., Roberts J. E. Meta-Analysis of the Relationship Between HIV Infection and Risk for Depressive Disorders. Am J Psychiatr. 2001; 158(5): 725–30.
Mohammed M, Mengistie B, Dessie Y, Godana W. Prevalence of depression and associated factors among HIV patients seeking treatments in ART Clinics at Harar town, eastern Ethiopia. J AIDS Clin Res. 2015; 6:474.
Hussain S, Devi N, Gupta AK, Azharuddin M. Prevalence and correlates of depression among HIV-positive patients in Bihar, India: a cross-sectional study. Sex Transm Infect. 2017; 93(2): A167.
Yun LWH, Maravi M, Kobayashi JS, Barton PL, Davidson AJ. Antidepressant treatment improves adherence to antiretroviral therapy among depressed HIV-infected patients. J Acquir Immune Defic Syndr. 2005; 38(4):432–38.
WHO. 2017. Let’s talk: Depression among people with HIV. Available at http://www.who.int/hiv/mediacentre/news/hiv-depdepession/en/ . Accessed May 19, 2018.
Bhatia MS, Munjal S. Prevalence of depression in people living with HIV/AIDS undergoing ART and factors associated with it. J Clin Diagn Res. 2014; 8(10): WC01-WC04.
Bongongo T, Tumbo J, Govender I. Depressive features among adult patients receiving antiretroviral therapy for HIV in Rustenburg district, SA. S Afr J Psych. 2013; 19(2): 31-4.
Bernard C, Dabis F, Rekeneire N. Prevalence and factors associated with depression in people living with HIV in sub-Saharan Africa: A systematic review and meta-analysis. PLoS ONE. 2017; 12(8): e0181960.
Onyebuchi-Iwudibia O, Brown Amy. HIV and depression in Eastern Nigeria: The role of HIV-related stigma. AIDS Care. 2014; 26(5): 653-7.
Aguocha CM, Uwakwe RU, Duru CB, Diwe KC, Aguocha JK, Enwere OO, and Olose EO. Prevalence and socio-demographic determinants of depression among patients attending HIV/AIDS Clinic in a teaching hospital in Imo State, Nigeria. Am J Med Sci Medic. 2015; 3(6): 106-12.
Adewuya AO, Afolabi MO, Ola BA, Ogundele OA, Ajibare OA, Oladipo BF. Psychiatric disorders among the HIV-positive population in Nigeria: a control study. J Psychosom Res. 2007; 63(2):203-6.
Olisah VO, Baiyewu O, Sheikh TL. Adherence to highly active antiretroviral therapy in depressed patients with HIV/AIDS attending a Nigerian university teaching hospital clinic. Afr J Psychiatr.2010; 13(4): 275-9.
Gibbie T, Mijch A, Ellen S, Hoy J, Hutchison C, Wright E et al. Depression and neuro-cognitive performance in individuals with HIV/AIDS: 2-year follow-up. HIV Medicine.2006; 7(2): 112-21.
Nanni MG, Caruso R, Mitchell AJ, Meggiolaro E, Grassi L. Depression in HIV infected patients: a review. Curr Psychiat Rep. 2015; 17(1): 530.
Hartzell JD, Janke IE, Weintrob AC. Impact of depression on HIV outcomes in the HAART era. J Antimicrob Chemother. 2008; 62(2):246-55.
Cameron IM, Crawford JR. Lawton K, Reid IC. Psychometric comparison of PHQ-9 and HADS for measuring depression severity in primary care. Br J Gen Pract. 2008; 58(546):32-6.
Kroenke K, Spitzer RL, WilliamJB. The PHQ-9: validity of a brief depression severity measure. J Gen Intern Med. 2001; 16(9):606-13.
Adewuya AO, Ola BA, Afolabi OO. Validity of the patient health questionnaire (PHQ-9) as a screening tool for depression amongst Nigerian university students. J Affect Dis. 2006; 96:89-93.
New York State Department of Health. Administering the Patient Health Questionnaires 2 and 9(PHQ 2 and 9) in integrated care settings. 2016. Available at: https://www.health.ny.gov/health_care/medicaid/redesign/dsrip/docs/2016-07-01_phq_2_and_9_clean.pdf . Accessed May 28, 2018.
Jekel JF, Katz DL, Elmore JG. Sample size, randomisation and probability theory. In; Epidemiology, biostatistics and preventive medicine. 2nd ed. Philadelphia, USA: W. B Saunders; 2001:194-9.
Obadeji A, Ogunlesi AO, Adebowale TO. Prevalence and predictors of depression in people living with HIV/AIDS attending an outpatient clinic in Nigeria. Iran Psychiatr Behav Sci. 2014; 8(1):26-31.
Adeyuwa AO. Afolabi MO, Ola BA, Ogundele OA, Ajibare AO, OLadipo BF, Fakande I. Relationship between depression and quality of life in persons with HIV infection in Nigeria. Int J Psych Med. 2008; 38(1):43-51.
Adeoti AO, Dada MU, Fadare JO. Prevalence of depression and anxiety disorders in people living with HIV/AIDS in a tertiary hospital in southwestern Nigeria. Med Rep Case Stud. 2018; 3(1):150.
Shittu RO, Issa BA, Olanrewaju GT, Mahmoud AO, Odeigah LO, Salami AK, Aderibigbe SA Prevalence and Correlates of depressive disorders among people living with HIV/AIDS, in north central Nigeria. J AIDS Clin Res. 2013; 4:11.1000251.
Lawler K, Mosepele M, Seloilwe E, Ratcliffe S, Steele K, Nthobatsang R et al. Depression among HIV-positive individuals in Botswana: A behavioral surveillance. AIDS Behav. 2011; 15(1):204-8.
Freeman, M., Nkomo, N., Kafaar, Z., & Kelly, K. Mental disorder in people living with HIV/AIDS in South Africa. S Afr J Psych. 2008; 38(3):489–500.
Kinyanda E, Hoskins S, Nakku J, Nawaz S, Patel V. Prevalence and risk factors of major depressive disorder in HIV/AIDS as seen in semi-urban Entebbe district, Uganda. BMC Psychiat. 2011; 11:205.
Ramjee G and Daniels B. Women and HIV in sub-Saharan Africa. AIDS Res Ther. 2013; 10(1):30.
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