Clinical Outcomes and Renal Safety in HIV/AIDS Patients on Tenofovir-containing Regimens in Lesotho

Molungoa Sello; Dorcas Rakumakoe; Martie Lubbe; Maseabata Ramathebane; Marike Cockeran

doi:doi:10.11648/j.jfmhc.20190504.11

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Clinical Outcomes and Renal Safety in HIV/AIDS Patients on Tenofovir-containing Regimens in Lesotho

Molungoa Sello, Dorcas Rakumakoe, Martie Lubbe, Maseabata Ramathebane, Marike Cockeran

Published in Journal of Family Medicine and Health Care (Volume 5, Issue 4)

Received: 13 August 2019 Accepted: 2 September 2019 Published: 9 October 2019

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Abstract

Although TDF use has been associated with acceptable safety, reports of rare manifestation of renal disease in HAART regimens that include TDF have been documented. The study was conducted at Paballong HIV/AIDS care centre in Berea, Lesotho. The aim of the study was to evaluate clinical outcomes and renal safety in HIV/AIDS patients taking TDF-containing HAART regimens. Descriptive, observational, longitudinal retrospective design was followed on 255 adults on TDF-containing HAART regimens at the study area; from October 2015 to March 2016. Data captured on a data collection tool included baseline, follow-up and end-line characteristics of clinical outcomes and renal safety. Patients gained an estimated body weight of to 0.10 kg from baseline (p < 0.05) at any age. Females were on average 2.49 kg heavier than males (p < 0.05). The CD4 cell count results estimated a daily increase of 0.20 cells/mm³ at any age. The mean CD4 cell count of female patients was 69.13 cells/mm³ higher than for males (p = 0.02). The eGFR results contended that sex, age and body weight are risk factors to developing renal insufficiency. The eGFR declined by 0.78 ml/min/1.73m² over the treatment duration at any age of treatment initiation (p < 0.05), while the average eGFR for females was lower (13.05 ml/min) (p < 0.05). Clinical outcomes manifesting by weight gain and CD4 cell count elevation improve at any age and better in females. The renal function is progressively deteriorated at any age and worsened in females.

Published in	Journal of Family Medicine and Health Care (Volume 5, Issue 4)
DOI	10.11648/j.jfmhc.20190504.11
Page(s)	38-44
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Tenofovir, Clinical Outcomes, Renal Safety, Longitudinal Study, Paballong HIV/AIDS Care Centre

References

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APA Style

Molungoa Sello, Dorcas Rakumakoe, Martie Lubbe, Maseabata Ramathebane, Marike Cockeran. (2019). Clinical Outcomes and Renal Safety in HIV/AIDS Patients on Tenofovir-containing Regimens in Lesotho. Journal of Family Medicine and Health Care, 5(4), 38-44. https://doi.org/10.11648/j.jfmhc.20190504.11

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ACS Style

Molungoa Sello; Dorcas Rakumakoe; Martie Lubbe; Maseabata Ramathebane; Marike Cockeran. Clinical Outcomes and Renal Safety in HIV/AIDS Patients on Tenofovir-containing Regimens in Lesotho. J. Fam. Med. Health Care 2019, 5(4), 38-44. doi: 10.11648/j.jfmhc.20190504.11

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AMA Style

Molungoa Sello, Dorcas Rakumakoe, Martie Lubbe, Maseabata Ramathebane, Marike Cockeran. Clinical Outcomes and Renal Safety in HIV/AIDS Patients on Tenofovir-containing Regimens in Lesotho. J Fam Med Health Care. 2019;5(4):38-44. doi: 10.11648/j.jfmhc.20190504.11

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@article{10.11648/j.jfmhc.20190504.11,
  author = {Molungoa Sello and Dorcas Rakumakoe and Martie Lubbe and Maseabata Ramathebane and Marike Cockeran},
  title = {Clinical Outcomes and Renal Safety in HIV/AIDS Patients on Tenofovir-containing Regimens in Lesotho},
  journal = {Journal of Family Medicine and Health Care},
  volume = {5},
  number = {4},
  pages = {38-44},
  doi = {10.11648/j.jfmhc.20190504.11},
  url = {https://doi.org/10.11648/j.jfmhc.20190504.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jfmhc.20190504.11},
  abstract = {Although TDF use has been associated with acceptable safety, reports of rare manifestation of renal disease in HAART regimens that include TDF have been documented. The study was conducted at Paballong HIV/AIDS care centre in Berea, Lesotho. The aim of the study was to evaluate clinical outcomes and renal safety in HIV/AIDS patients taking TDF-containing HAART regimens. Descriptive, observational, longitudinal retrospective design was followed on 255 adults on TDF-containing HAART regimens at the study area; from October 2015 to March 2016. Data captured on a data collection tool included baseline, follow-up and end-line characteristics of clinical outcomes and renal safety. Patients gained an estimated body weight of to 0.10 kg from baseline (p p 3 at any age. The mean CD4 cell count of female patients was 69.13 cells/mm3 higher than for males (p = 0.02). The eGFR results contended that sex, age and body weight are risk factors to developing renal insufficiency. The eGFR declined by 0.78 ml/min/1.73m2 over the treatment duration at any age of treatment initiation (p p < 0.05). Clinical outcomes manifesting by weight gain and CD4 cell count elevation improve at any age and better in females. The renal function is progressively deteriorated at any age and worsened in females.},
 year = {2019}
}

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TY  - JOUR
T1  - Clinical Outcomes and Renal Safety in HIV/AIDS Patients on Tenofovir-containing Regimens in Lesotho
AU  - Molungoa Sello
AU  - Dorcas Rakumakoe
AU  - Martie Lubbe
AU  - Maseabata Ramathebane
AU  - Marike Cockeran
Y1  - 2019/10/09
PY  - 2019
N1  - https://doi.org/10.11648/j.jfmhc.20190504.11
DO  - 10.11648/j.jfmhc.20190504.11
T2  - Journal of Family Medicine and Health Care
JF  - Journal of Family Medicine and Health Care
JO  - Journal of Family Medicine and Health Care
SP  - 38
EP  - 44
PB  - Science Publishing Group
SN  - 2469-8342
UR  - https://doi.org/10.11648/j.jfmhc.20190504.11
AB  - Although TDF use has been associated with acceptable safety, reports of rare manifestation of renal disease in HAART regimens that include TDF have been documented. The study was conducted at Paballong HIV/AIDS care centre in Berea, Lesotho. The aim of the study was to evaluate clinical outcomes and renal safety in HIV/AIDS patients taking TDF-containing HAART regimens. Descriptive, observational, longitudinal retrospective design was followed on 255 adults on TDF-containing HAART regimens at the study area; from October 2015 to March 2016. Data captured on a data collection tool included baseline, follow-up and end-line characteristics of clinical outcomes and renal safety. Patients gained an estimated body weight of to 0.10 kg from baseline (p p 3 at any age. The mean CD4 cell count of female patients was 69.13 cells/mm3 higher than for males (p = 0.02). The eGFR results contended that sex, age and body weight are risk factors to developing renal insufficiency. The eGFR declined by 0.78 ml/min/1.73m2 over the treatment duration at any age of treatment initiation (p p < 0.05). Clinical outcomes manifesting by weight gain and CD4 cell count elevation improve at any age and better in females. The renal function is progressively deteriorated at any age and worsened in females.
VL  - 5
IS  - 4
ER  -

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Author Information

Molungoa Sello

Department of Pharmacy, National University of Lesotho, Roma, Lesotho
Dorcas Rakumakoe

Medicine Usage in South Africa, North-West University, Potchefstroom, South Africa
Martie Lubbe

Medicine Usage in South Africa, North-West University, Potchefstroom, South Africa
Maseabata Ramathebane

Department of Pharmacy, National University of Lesotho, Roma, Lesotho
Marike Cockeran

Medicine Usage in South Africa, North-West University, Potchefstroom, South Africa

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APA Style

Molungoa Sello, Dorcas Rakumakoe, Martie Lubbe, Maseabata Ramathebane, Marike Cockeran. (2019). Clinical Outcomes and Renal Safety in HIV/AIDS Patients on Tenofovir-containing Regimens in Lesotho. Journal of Family Medicine and Health Care, 5(4), 38-44. https://doi.org/10.11648/j.jfmhc.20190504.11

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ACS Style

Molungoa Sello; Dorcas Rakumakoe; Martie Lubbe; Maseabata Ramathebane; Marike Cockeran. Clinical Outcomes and Renal Safety in HIV/AIDS Patients on Tenofovir-containing Regimens in Lesotho. J. Fam. Med. Health Care 2019, 5(4), 38-44. doi: 10.11648/j.jfmhc.20190504.11

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AMA Style

Molungoa Sello, Dorcas Rakumakoe, Martie Lubbe, Maseabata Ramathebane, Marike Cockeran. Clinical Outcomes and Renal Safety in HIV/AIDS Patients on Tenofovir-containing Regimens in Lesotho. J Fam Med Health Care. 2019;5(4):38-44. doi: 10.11648/j.jfmhc.20190504.11

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@article{10.11648/j.jfmhc.20190504.11,
  author = {Molungoa Sello and Dorcas Rakumakoe and Martie Lubbe and Maseabata Ramathebane and Marike Cockeran},
  title = {Clinical Outcomes and Renal Safety in HIV/AIDS Patients on Tenofovir-containing Regimens in Lesotho},
  journal = {Journal of Family Medicine and Health Care},
  volume = {5},
  number = {4},
  pages = {38-44},
  doi = {10.11648/j.jfmhc.20190504.11},
  url = {https://doi.org/10.11648/j.jfmhc.20190504.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jfmhc.20190504.11},
  abstract = {Although TDF use has been associated with acceptable safety, reports of rare manifestation of renal disease in HAART regimens that include TDF have been documented. The study was conducted at Paballong HIV/AIDS care centre in Berea, Lesotho. The aim of the study was to evaluate clinical outcomes and renal safety in HIV/AIDS patients taking TDF-containing HAART regimens. Descriptive, observational, longitudinal retrospective design was followed on 255 adults on TDF-containing HAART regimens at the study area; from October 2015 to March 2016. Data captured on a data collection tool included baseline, follow-up and end-line characteristics of clinical outcomes and renal safety. Patients gained an estimated body weight of to 0.10 kg from baseline (p p 3 at any age. The mean CD4 cell count of female patients was 69.13 cells/mm3 higher than for males (p = 0.02). The eGFR results contended that sex, age and body weight are risk factors to developing renal insufficiency. The eGFR declined by 0.78 ml/min/1.73m2 over the treatment duration at any age of treatment initiation (p p < 0.05). Clinical outcomes manifesting by weight gain and CD4 cell count elevation improve at any age and better in females. The renal function is progressively deteriorated at any age and worsened in females.},
 year = {2019}
}

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TY  - JOUR
T1  - Clinical Outcomes and Renal Safety in HIV/AIDS Patients on Tenofovir-containing Regimens in Lesotho
AU  - Molungoa Sello
AU  - Dorcas Rakumakoe
AU  - Martie Lubbe
AU  - Maseabata Ramathebane
AU  - Marike Cockeran
Y1  - 2019/10/09
PY  - 2019
N1  - https://doi.org/10.11648/j.jfmhc.20190504.11
DO  - 10.11648/j.jfmhc.20190504.11
T2  - Journal of Family Medicine and Health Care
JF  - Journal of Family Medicine and Health Care
JO  - Journal of Family Medicine and Health Care
SP  - 38
EP  - 44
PB  - Science Publishing Group
SN  - 2469-8342
UR  - https://doi.org/10.11648/j.jfmhc.20190504.11
AB  - Although TDF use has been associated with acceptable safety, reports of rare manifestation of renal disease in HAART regimens that include TDF have been documented. The study was conducted at Paballong HIV/AIDS care centre in Berea, Lesotho. The aim of the study was to evaluate clinical outcomes and renal safety in HIV/AIDS patients taking TDF-containing HAART regimens. Descriptive, observational, longitudinal retrospective design was followed on 255 adults on TDF-containing HAART regimens at the study area; from October 2015 to March 2016. Data captured on a data collection tool included baseline, follow-up and end-line characteristics of clinical outcomes and renal safety. Patients gained an estimated body weight of to 0.10 kg from baseline (p p 3 at any age. The mean CD4 cell count of female patients was 69.13 cells/mm3 higher than for males (p = 0.02). The eGFR results contended that sex, age and body weight are risk factors to developing renal insufficiency. The eGFR declined by 0.78 ml/min/1.73m2 over the treatment duration at any age of treatment initiation (p p < 0.05). Clinical outcomes manifesting by weight gain and CD4 cell count elevation improve at any age and better in females. The renal function is progressively deteriorated at any age and worsened in females.
VL  - 5
IS  - 4
ER  -

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